“The Best Breathing Exercises for COVID-19: Before` During` - Healthline” plus 2 more
“The Best Breathing Exercises for COVID-19: Before` During` - Healthline” plus 2 more |
- The Best Breathing Exercises for COVID-19: Before` During` - Healthline
- A child with SARS‐CoV2‐induced croup - Tsoi - - Pediatric Pulmonology - Wiley
- [Full text] Clinical Analysis of mNGS confirmed C. psittaci pneumonia | IDR - Dove Medical Press
| The Best Breathing Exercises for COVID-19: Before` During` - Healthline Posted: 13 Apr 2021 08:01 AM PDT Breathing exercises can strengthen the lungs and may be beneficial for reducing the impact of COVID-19 before, during, and after it strikes. The breathing exercises we outline in this article won't prevent COVID-19, but they may help mitigate the symptoms affecting your respiratory system. They are also helpful for alleviating stress you may be feeling in the midst of this pandemic. As we've come to know, COVID-19 presents differently in different people. Inflammation in the lungs and airways are common symptoms that make breathing difficult. These symptoms can accompany mild, moderate, or severe COVID. People who get very sick from COVID-19 may experience pneumonia as a result. This causes the lungs to fill with fluid and mucus, making it even harder to breathe and get the oxygen your body needs to function. If you have a condition such as chronic obstructive pulmonary disease (COPD) or moderate to severe asthma, you may already have reduced lung capacity and trouble breathing. These conditions cause chronic inflammation of the lungs, which can significantly worsen in people who get COVID-19. COVID affects the entire respiratory tract, further obstructing airflow. It can trigger asthma attacks and cause acute respiratory distress syndrome (ARDS). Deep breathing exercises that clear the lungs and strengthen lung function may be especially beneficial for people with these conditions. Breathing exercises get oxygen deep into the lungs, which helps you clear out mucus and other fluids. During recovery, breathing exercises work to strengthen the diaphragm, a major respiratory muscle located under the lungs. It can also help increase lung capacity, bringing much-needed oxygen into your bloodstream. Deep breathing exercises also help you feel calm, which may be beneficial for coping with long-term illness and recovery. Breathing exercises do not prevent COVID-19 and should not be used in place of mask wearing, social distancing, or getting vaccinated. Breathing exercises can, however, strengthen your lungs, which may reduce COVID-19's impact on your respiratory system. A systematic review and meta-analysis of 19 randomized controlled studies found that breathing techniques, such as pursed lips breathing, reduce shortness of breath. Breathing exercises also improved lung ventilation, which is the ability of the lungs to expel carbon dioxide and stale air. Pursed lip breathingPursed lip breathing gets more oxygen into your lungs than regular breathing can. It also keeps your airways open longer by reducing the number of breaths you take per minute. Follow these steps to try pursed lip breathing:
 Aerobic exerciseAny form of energetic exercise that makes you breathe more quickly is, in essence, a breathing exercise. This includes brisk walking, running, swimming, or any activity that increases heart rate and breathing rate. Exercising regularly supports lung health. And healthy lungs may be your best defense against COVID-19, should you become infected. COVID-19 is a respiratory illness caused by a coronavirus. According to the Centers for Disease Control and Prevention (CDC), the most common symptoms of COVID-19 include:
Or if you one of these symptoms or conditions:
In people with acute COVID, symptoms usually start between 2 and 14 days after exposure and resolves within 2 weeks. Some people have lingering symptoms, such as shortness of breath and fatigue for a longer period of time. If you have COVID-19, talk with your doctor before starting breathing exercises. If you have shortness of breath while resting, an irregular heartbeat, or chest pain, you may worsen your symptoms by exercising. In addition to pursed lip breathing, other breathing exercises may also help while recuperating from COVID-19. An analysis of multiple studies by integrative medicine practitioners found that Qigong, a practice that utilizes deep breathing and slow movements, improved pulmonary function and increased lung capacity in COVID-19 patients. Qigong belly breathing (diaphragmatic breathing)
COVID-19 long-haulers have chronic COVID. If you are a long-hauler, you may continue to have symptoms for weeks or months after infection. These symptoms vary but can include:
Breathing exercises may help improve lung function in long haulers. They may also help to reduce ongoing stress and anxiety caused by COVID symptoms. Yawn to a SmileThis breathing exercise opens up the muscles in the chest, which allows the diaphragm to fully expand. It also strengthens the arms and shoulder muscles. Here's how to do it:
Humming while exhalingHumming, such as the chanting of "om" in yoga, can help pull oxygen into the lungs with each breath. Many also find it can be calming. Here are the steps for this exercise:
Most people who get COVID-19 make a full recovery, often within a few weeks. Serious cases of COVID can take a month or longer to completely resolve. Rebuilding lung capacity can help aid your recovery, whether or not you had complications such as pneumonia or were placed on a ventilator. Breathing exercises deepen each breath, improving the exchange of oxygen and carbon dioxide in the lungs. This improves overall lung capacity. Breathing exercises also induce a feeling of calm — a valuable component of recovery and quality of life. If you're using breathing exercises to help with your recovery, don't rush it. You may have to start slowly and build up to multiple repetitions during the healing process. Aerobic exercise can also help strength your lungs significantly. Just make sure to go slow and not overdo it. | ||||||||||||
| A child with SARS‐CoV2‐induced croup - Tsoi - - Pediatric Pulmonology - Wiley Posted: 15 Apr 2021 09:01 PM PDT  Children with coronavirus disease 2019 (COVID‐19), an infection caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are usually asymptomatic or only mildly symptomatic. The most common symptoms are coryzal in nature including fever and cough.1 Most children are clinically stable1 and require no medical intervention. However, despite their stable condition, stringent infection control measures are still required. In this letter, we describe a child infected with SARS‐CoV‐2 who presented atypically with croup features. With the current COVID‐19 pandemic, infection control measures need to be appropriately heightened and early diagnostic sampling for SARS‐CoV‐2 should be carried out even in symptomatology that is atypical of COVID‐19. A 21‐month‐old boy was admitted with a 1‐day history of fever, noisy breathing, mild cough, and hoarseness. The cough was not "barking" and there were no drooling, gastrointestinal, or urinary symptoms. On examination, he was febrile at 40.2°C, respiratory rate was 32–36/min and SpO2 was 94%–97% in room air. He had hoarseness and exhibited inspiratory stridor during vigorous cry. Breath sounds were vesicular, air entry bilaterally equal and no other signs were present. The clinical features were compatible with mild croup. In view of a history of close contact 5 days before admission with his maternal grandmother who was confirmed as SARS‐CoV‐2 positive 3 days ago he was tested for SARS‐CoV‐2. He tested positive for SARS‐CoV‐2 by nasopharyngeal swab (NPS) PCR on admission with a Ct value of 16.4. NPS was negative for other respiratory pathogens including adenovirus, human metapneumovirus, human enterovirus/rhinovirus, influenza A, influenza B, parainfluenza types 1‐4, respiratory syncytial virus, Bordetella pertussis, Chlamydia pneumoniae, and Mycoplasma pneumoniae. The chest radiograph showed a positive steeple sign and no consolidation. He was treated for croup with one dose of 0.6 mg/kg oral dexamethasone on Day 1 of illness. The symptoms improved initially but deteriorated 12 h after the first dexamethasone dose with worsening of tachypnoea and persistence of stridor with agitation. A second dose of 0.6 mg/kg dexamethasone was given on Day 2 of illness. There was then gradual resolution of noisy breathing and tachypnoea. His cough and sputum sounds subsided on Day 9 but the hoarseness persisted till Day 15. NPS SARS‐CoV‐2 PCR Ct value rose to 31.78 by Day 9 and 35 by Day 18. Blood for SARS‐CoV‐2 antibody was positive by Day 19. The patient was asymptomatic by that time and was discharged. Croup is a common viral infection in the pediatric population that is usually associated with parainfluenza, rhinovirus, and respiratory syncytial virus infections. Children with croup usually present with a characteristic barking cough, stridor, and respiratory distress. Compared with COVID‐19, for croup, the presentation and initial management strategies are distinctly different. Treatment including dexamethasone and nebulized adrenaline can be considered. Croup is usually diagnosed by clinical assessment. Healthcare workers deliberately avoid uncomfortable procedures such as blood‐taking and nasopharyngeal sampling in these children as agitating the child may worsen any airway obstruction. Croup symptoms usually last for 2–3 days and sometimes up to 1 week. Our case was an uncommon manifestation of pediatric SARS‐CoV‐2 infection. Very few cases of SARS‐CoV‐2 infection presenting with features of croup have been reported in the literature. Pitstick et al.2 reported a SARS‐CoV‐2 positive case with fever, cough, and intermittent stridor, while Venn et al.3 reported three SARS‐CoV‐2 positive cases with the first case exhibiting fever, cough, and stridor; the second case cough and dyspnea without fever; and the third child fever, tachypnoea and inspiratory stridor at rest. Our patient had persistent symptoms lasting 15 days which is much longer than the usual 2–3 days. Such prolonged symptomatology is unusual amongst pediatric COVID‐19 cases1 and also uncommon amongst children with croup. Apart from this, the presentation of croup caused by SARS‐CoV‐2 is similar to that of those caused by parainfluenza type 1. Patients described by Pitstick and Venn also had similar presentations as per usual parainfluenza croup, so whether SARS‐CoV‐2 can cause a longer duration of symptoms for croup remains to be seen. Nasopharyngeal aspiration (NPA) is an aerosol‐generating procedure, that should be carried out in an airborne infection isolation room (AIIR) by staff protected with adequate personal protective equipment (PPE). In our practice, patients with croup usually are not tested for fear of the risk of airway obstruction when agitating the child. As symptoms of croup caused by parainfluenza virus and SARS‐CoV‐2 are similar, it would be difficult to differentiate the two by clinical assessment alone. However, the implications regarding aerosol‐generating procedures, isolation facilities, and treatment may be very different. Hence, under the current pandemic, we would recommend to proceed with early testing in children presenting with clinical features of croup so that appropriate treatment and infection control measures may be instituted. As there is a risk of worsening airway obstruction with sampling, expertise, and equipment needed for advanced airway support should be available while the patient is undergoing nasopharyngeal sampling. Instead of NPAs, alternative sampling such as throat swabs or NPSs for SARS‐CoV‐2 may be considered to minimize aerosol generation as much as possible. Patients with croup are often treated with oral dexamethasone. For more serious cases, nebulized adrenaline may be considered. Should nebulized adrenaline be indicated, medical staff should wear full PPE and administer a nebulizer in AIIR. In case AIIR and adequate PPE are unavailable, there is limited evidence supporting the use of a metered‐dose inhaler for epinephrine delivery.4 Repeated doses of dexamethasone should be considered if appropriate. In case of deterioration, early intubation should be considered by medical personnel equipped with appropriate PPE and nebulized medication can be administered via a closed ventilatory circuit. In conclusion, under the current COVID‐19 pandemic, even for children presenting atypically, for example, with croup, after careful consideration of patient's clinical condition, availability of PPE and AIIR and choice of treatment, early testing for SARS‐CoV‐2 is still strongly recommended. Clinicians may consider waiting for approximately 2 h for an initial dose of dexamethasone to take effect.5 Appropriate detection of children with SARS‐CoV‐2 infection is important to help prevent the spread of disease, and patients should also remain housed in an AIIR if possible. CONFLICT OF INTERESTSThe authors declare that there are no conflict of interests. AUTHOR CONTRIBUTIONSKathleen Tsoi: conceptualization (equal); writing original draft (equal); writing review and editing (equal). Kate C. Chan: conceptualization (equal); writing review and editing (equal). Geoffrey Mok: conceptualization (equal); supervision (equal). Albert M. Li: conceptualization (equal); supervision (equal); writing review and editing (equal). Hugh S. Lam: conceptualization (equal); supervision (equal); writing review and editing (equal). KEYWORDSCOVID‐19, croup, viral infection, SARS‐CoV‐2 | ||||||||||||
| [Full text] Clinical Analysis of mNGS confirmed C. psittaci pneumonia | IDR - Dove Medical Press Posted: 15 Apr 2021 05:17 PM PDT Xin-Qi Teng,1,* Wen-Cheng Gong,2,* Ting-Ting Qi,1 Guo-Hua Li,1 Qiang Qu,3 Qiong Lu,1 Jian Qu1 1Department of Pharmacy, The Second Xiangya Hospital, Central South University; Institute of Clinical Pharmacy, Central South University, Changsha, People's Republic of China; 2Department of Pharmacy, Jiangxi Cancer Hospital of Nanchang University, Jiangxi Cancer Center, Nanchang, Jiangxi, People's Republic of China; 3Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, People's Republic of China Correspondence: Jian Qu Introduction: Chlamydia psittaci infection is a zoonotic infectious disease, which mainly inhaled through the lungs when exposed to the secretions of poultry that carry pathogenic bacteria. The traditional respiratory specimens or serological antibody testing is slow, and the false-negative rate is high. Metagenomic next-generation sequencing (mNGS) gives a promising rapid diagnosis tool. IntroductionChlamydia psittaci pneumonia is caused by Chlamydia psittaci (C. psittaci), which can lead to severe pneumonia, adult respiratory distress syndrome, and even death.1 According to the sequence difference of C. psittaci outer membrane protein A gene (ompA), it can be divided into 10 genotypes, namely A-G, WC, E/B, and M56, among which genotype A is the main genotype that causes human infection.2 About 70% of respiratory tract infections caused by C. psittaci are asymptomatic or only with mild symptoms, but 30% of them are severe respiratory illnesses such as community-acquired pneumonia with atypical symptoms, bronchitis, and upper respiratory tract infections.3 Contacting with birds or poultry is regarded as the main risk factor for psittacosis.1 The clinical symptoms of C. psittaci infection are quite different and lack specificity, which ranges in severity from mild to severe. Since the clinical manifestations of C. psittaci are similar to influenza symptoms, and the extrapulmonary manifestations are similar to Legionella, it needs to be differentiated from influenza and Legionella.4 Recent publications also reported the co-infection of SARS-CoV-2 with Chlamydia,5–7 which makes infectious diseases more complex. The culture of C. psittaci from respiratory secretions in special media is possible but difficult, and it is mainly performed in specialized laboratories only because of the high infectivity of this pathogen. Specific diagnostic testing is serological, which is regarded as the gold standard for C. psittaci pneumonia. Moreover, the micro-immunofluorescence test (MIF) is the most accurate serologic test for C. psittaci pneumonia but is also performed only in specialized laboratories. Polymerase chain reaction assay (PCR) is used to confirm the strong clinical suspicion of a possible diagnosis of psittacosis especially, to distinguish it from other chlamydial species.8 And complement fixation (CF) is also an acceptable diagnostic method. Detection methods for C. psittaci, such as PCR, CF, and MIF are not routinely available in most hospitals in China. Because of its non-specific symptoms and the limitations of traditional tests, C. psittaci pneumonia is easily underdiagnosed and misdiagnosed.9 Metagenomic next-generation sequencing (mNGS) can quickly and accurately identify potential pathogens, whether they are bacteria, fungi, viruses, or parasites.10 It is increasingly used for the diagnosis of infectious diseases, especially when traditional diagnostic methods have limitations.11 Studies have shown that mNGS is the most promising comprehensive diagnosis method for infection, especially for severe pneumonia.12 Recently, several studies have reported the application of mNGS in diagnosing C. psittaci pneumonia, two case reports describing 5 and 9 cases of C. psittaci diagnosed by mNGS13,14. We retrospectively summarized the clinical characteristics of five C. psittaci pneumonia patients diagnosed by mNGS in our hospital. Besides, we conducted a literature review of patients with C. psittaci pneumonia reported since 2010, with the attention to summarize the diagnostic methods and anti-infective drugs. We also summarized the clinical outcome and history of exposure to avian or poultry of these infection patients to provide a reference for future C. psittaci pneumonia infection patients' diagnosis and treatment. We present the following article following the CARE reporting checklist. Case PresentationsPatients' InformationWe carried out a retrospective case series analysis of five patients admitted to the Second Xiangya Hospital of Central South University since 2018. We collected the clinical data of all patients confirmed to have C. psittaci pneumonia. Sex, age, clinical examination indexes such as procalcitonin (PCT), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), comprehensive computed tomography (CT), and arterial blood gas analysis were extracted from electronic medical records. The treatment of antibiotics, outcomes, and any relevant follow-up data were also collected. The Ethics Committees of the Second Xiangya Hospital of Central South University (LYF-2020021) approved this study. Informed consent was obtained from patients and guardians. This study was carried out by the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All data were anonymized before analysis. As the symptoms of the patients were sudden, some patients had no sputum and their blood oxygen saturation was low, we did not perform bronchoscopy for them on admission. The blood was used for performing mNGS testing on admission for all five patients, and only case 5 performed bronchoalveolar lavage fluid (BAFL) mNGS testing on admission. All five patients were positive for C. psittaci DNA fragments in the blood mNGS test. Moreover, BAFL mNGS of case 5 result showed Klebsiella DNA fragments. The median duration from admission to the mNGS pathogenic diagnosis of the 5 cases was 3 days (range from 2 to 4). The median of mNGS detection sequence number of C. psittaci was 217 (range from 175 to 289). No pathogenic microorganisms were found in the sputum, BAFL, and blood culture of the patient after admission to our hospital. We also conducted serological verification and PCR for five cases after an atypical pathogen was identified by mNGS. Serological detection of antibody to C. pneumoniae was positive only in case 2 and the PCR of C. pneumoniae was negative in all patients. While the serological detection of antibody, PCR, MIF, and CF of C. psittaci cannot be performed in our hospital. There were three male and two female patients with a median age of 51 years (range from 36 to 66). 60% of patients had type 2 diabetes. Three of five patients had a history of contact with avian or poultry. All patients had a high fever over 38.5 °C, cough, hypodynamia, hypoxemia, and dyspnea. Two of five patients had a headache. In the course of treatment, two patients had invasive ventilator support and Extracorporeal Membrane Oxygenation (ECOM) support. The medium APACHE II was 17.6 (range from 8 to 22). Days from illness to respiratory failure were 4.8 (2–8) days. Laboratory TestmNGS was conducted using the following operational steps according to the company's operating procedures (The Beijing Genomics Institute, Beijing, China). Briefly, clinical samples (blood or BALF)) were collected by following the standards of aseptic processing procedures. Nucleic acid extraction was conducted and the extracted DNA was subjected to processes of interruption, end repair, library construction, and sequencing. The mapped data were processed for advanced data analysis. Lists of suspected pathogenic microorganisms were produced, which included the numbers of strictly mapped reads, coverage rates, and depth. The clinical diagnosis was determined by considering all the clinical manifestations, possible pathogens identified by mNGS, and other laboratory tests together. On admission and during the hospital, inflammatory markers such as PCT, CRP, ESR, kidney, and liver function index, CT, and X-ray data were detected according to the patients' condition. Laboratory inspection parameters of the five patients on admission were shown in Table 2. Four patients had lower hemoglobin and the levels were 108.6 (range 68–148) g/L. The levels of CRP, PCT, and ESR on admission were all higher than normal values. Oxygen partial pressure and partial pressure of carbon dioxide of all patients were significantly lower than normal values.
After admission, follow-up laboratory testing results showed that the levels of inflammatory markers including WBC, percentage of neutrophils, CRP, PCT, ESR were all higher than normal values (Table 1). Moreover, the values of CK, lactate dehydrogenase (LDH), ALT, and AST were all higher than normal values in all five patients. Three patients had hypokalemia and the potassium levels were range from 2.7 to 3.3 mmol/L. Chest CT and X-ray of patients showed that lungs were exuding consolidation foci, bilateral pectoral effusions, consolidation. After treatment, the image of four patients improved compared with those on admission, and the patients' lung exudation, consolidation, and bilateral pleural effusion were less than before (Figures 1 and 2).
Treatment and OutcomeAfter C. psittaci pneumonia was confirmed, one of the three male patients received symptomatic anti-infective treatment with moxifloxacin (400mg ivgtt qd) and with adjuvant non-invasive ventilator therapy. The other two male patients received symptomatic anti-infective therapy with doxycycline (100mg po q12h) and were treated with high flow nasal cannula therapy. All three male patients were improved and discharged after more than 10 days of treatment. Two female patients were transferred to our hospital after invasive ventilator adjuvant treatment with tracheal intubation from other hospitals. They were treated with moxifloxacin (400mg ivgtt qd) combined with doxycycline (100mg po q12h) for symptomatic anti-infective therapy. The two female patients were treated with ECOM and ventilator adjuvant therapy due to their critical illness. One patient was removed ECOM after five days of treatment with blood oxygen saturation and oxygen partial pressure was significantly improved. After 3 days of consecutive treatment, the invasive ventilator was removed. The patient continued to receive treatment and was discharged from the hospital. Another 35-years old female patient (case 5) was critically ill and the disease progressed rapidly and finally die. One week before admission, the B-mode ultrasound showed that the patient was in early intrauterine pregnancy with a size of about 6 weeks, with no germ and heartbeat. The patient was transferred to the respiratory ICU of our hospital after oral endotracheal intubation with a high fever of 39 °C and blood oxygen saturation of 65%. Chest radiograph showed multiple exudative lesions in both lungs and pleural effusion on the right side. After admission, she was given meropenem combined with moxifloxacin and ganciclovir. On the third day after admission, mNGS of blood indicated C. psittaci, with a sequence number of 533. mNGS of BAFL indicated Klebsiella pneumoniae, with a sequence number of 175. Then the patient was given an injection of doxycycline. On the 7th day of admission, the patient's blood oxygen saturation was still 70% (through endotracheal intubation and invasive ventilator), and ECMO treatment was performed. On the 8th day of admission, the patient died due to septic shock, disseminated intravascular coagulation (DIC), and multiple organ failures. Literature ReviewWe searched the databases including PubMed, EMBASE, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure (CNKI) from 1st Jan. 2010 to 1st Oct. 2020. The searching strategy was "Chlamydia psittaci" or "Chlamydia psittaci pneumonia". Dr. Jian Qu and Dr. Wen-Cheng Gong reviewed all relevant articles to identify potentially eligible studies. We conducted this literature review of patients with C. psittaci pneumonia to summarize the diagnostic methods and anti-infective drugs, and we also summarized the clinical outcome and history of exposure to avian or poultry of these infection patients to provide a reference for future C. psittaci pneumonia infection patients' diagnosis and treatment. The data about authors, reported time, number of cases, ethnics, history of exposure to avian or poultry, anti-infective drugs regiment, and clinical outcome were collected. We found 794 publications. After excluded the full text could not be found or provided no information we needed about C. psittaci pneumonia or no original data or the Chlamydia was not specified. Finally, 19 articles were enrolled in further review. The summary of the detailed information was shown in Table 3. The articles were published from 2012 to 2020. With the development of detection technology, the number of articles reported tends to increase (Figure 3). Since 2019, there were 13 articles reported C. psittaci pneumonia and among them, 10 articles using mNGS to detect C. psittaci. There was a total of 69 C. psittaci pneumonia patients were reported and most patients had a history of exposure to avian or poultry. Most patients treated with doxycycline, moxifloxacin, meropenem, or their combinations, and three patients used ECOM support. Most of the patients' treatment improved and four patients died.
DiscussionWe retrospectively analyzed five cases of psittacosis pneumonia diagnosed using mNGS and summarized the clinical characteristics including disease progression, treatments, and outcomes, etc. Moreover, we also carried out a literature review that summarized the existing research and reports about C. psittaci pneumonia. In our study, five C. psittaci pneumonia patients confirmed by mNGS aged from 36 to 66 years with three males. 60% of patients had underlying diseases Type 2 diabetes. Three of these five patients had a history of contact with avian or poultry. All patients had a high fever over 38.5 °C, cough, hypodynamia, hypoxemia, and dyspnea on admission. Two patients had invasive ventilator support and ECOM support. The levels of CRP, PCT, and ESR on admission and follow-up were all higher than normal values. Doxycycline or moxifloxacin monotherapy was accounted for 1/5 (20%) and 2/5 (40%) patients, and combination therapy was accounted for 2/5 (40%) patients. Four patients improved and were discharged, and one patient died due to multiple organ failures and disseminated intravascular coagulation. The lung manifestations are mainly cough, dry cough, shortness of breath, the rapid progress of lung disease, and occasionally acute respiratory distress syndrome (ARDS).15 In the five cases reported in this article, 3 patients had ARDS. And there were even case reports showing only abnormal liver function.16 In the initial auscultation, the lung lesions of C. psittaci pneumonia were often underestimated. The chest radiograph showed infiltrating patches with uneven density, which can seriously affect all lung lobes. CT of the lungs showed consolidation or ground glass-like changes, especially the lower lung, with pleural involvement and pleural effusion.17 After treatment, the patients' cough and fever improved, but the oxygenation index recovered slowly. According to the reporting of literature, the absorption of the lesion was slow, with an average absorption time of 6 weeks, up to 20 weeks.18 The laboratory inspection parameters of the five patients on admission showed that two patients had WBC > 10×109/L, and three cases had PCT > 10 ng/mL, and the chest radiology presented mainly consolidation. The mNGS detection of case 5 also showed Klebsiella pneumoniae infection in addition to C. psittaci infection, but there were no other bacteria was isolated in the other four cases. Although other bacteria were not found in culture, other bacterial coinfections cannot be ruled out because of the high WBC and PCT value, and the chest radiology characterized by consolidation. Especially, some patients were carried out invasive ventilator support or ECOM. Therefore, patients are at risk for hospital-acquired pneumonia and ventilator-associated pneumonia infection. Before admission, the community-acquired pneumonia was also treated with antibiotics such as cephalosporins and quinolones in other hospitals before the diagnosis of C. psittaci pneumonia. According to the control requirements of C. psittaci issued by the National Public Health Veterinary Association, the confirmed diagnosis of human C. psittaci pneumonia only needs to meet one of the following two standards: 1). Isolate C. psittaci from respiratory specimens (sputum, pleural fluid, tissue, etc.) or blood specimens 2). Serological examination: Measure the C. psittaci IgG antibody in the acute and convalescent phases during the interval of 2–4 weeks, the convalescent phase is more than four times higher than the acute phase. If the patient meets one of the following two standards, it may be infected: 1). Serum examination, C. psittaci IgM ≥ 32; 2). C. psittaci DNA can be detected through PCR amplification of respiratory specimens (sputum, pleural fluid, tissue, etc.).19 Since C. psittaci is strictly intracellular parasitic, its direct isolation and cultivation are very difficult and cannot be carried out routinely. At present, the clinical presentation and the positive serological result using MIF with paired sera are the most often used diagnostic methods of C. psittaci.1 MIF20 and PCR gene expansion detection have become auxiliary detection of molecular biological diagnosis due to their high sensitivity and specificity.21 Although MIF is more sensitive and specific than complement fixation (CF) tests, the test still displays cross-reactivity with other Chlamydia species in some instances.22 PCR testing is not clinical laboratory improvement amendments validated currently. mNGS can be used to detect pathogens that cannot be detected by traditional methods.23 Patients introduced in this article were all severely infected when they were admitted to our hospital, with respiratory failure, and dry cough without sputum. Due to the high risk of bronchoscopy and difficulty in taking respiratory tract specimens, the blood or BAFL samples of patients were sent out for mNGS testing and finally reported C. psittaci infection. Early pathogenic diagnosis can greatly benefit patients, and of the 5 patients reported in this article, 4 patients improved and were discharged. Our literature review also found that with the development of technology, the number of C. psittaci detected increased year by year, and the articles reported C. psittaci pneumonia via mNGS increased year by year (Figure 3 and Table 3). Tetracyclines, macrolides, and quinolones can interfere with DNA and protein synthesis, therefore, these three kinds of antibiotics can be used to treat C. psittaci.24 At present, both in China and other country, tetracyclines are the first choice for the treatment of C. psittaci pneumonia including tetracycline, doxycycline, and minocycline.25,26 In severe cases, doxycycline can be administered intravenously. The treatment of the patient in case 2 with doxycycline is also effective. Macrolide drugs such as azithromycin and fluoroquinolones have been confirmed to have antibacterial activity against C. psittaci in vitro,26,27 In particular, moxifloxacin has strong antibacterial activity against Chlamydia, and there are case reports at home and abroad that the use of fluoroquinolone drugs is effective.28–31 Given the lack of experience in the use of tetracyclines in our hospital, Chlamydia trachomatis, which is the same species as C. psittaci in my country, is highly resistant to tetracycline,32 so the treatment for case 1 patient used moxifloxacin and it was effective. After five patients were treated, four patients were improved and discharged. Among them, one patient was treated with moxifloxacin, two patients were treated with doxycycline, and the other two patients were treated with moxifloxacin plus doxycycline. Current C. psittaci Pneumonia treatment guidelines recommend the addition of macrolide or quinolone to the initial regimen of severe C. psittaci in any case. According to current reports, it is unclear whether combination medication is more effective than single medication for patients. Further case-control studies with larger samples are needed to find the optimal treatment. In this article, we have searched the relevant literature. At present, most cases of human infection with C. psittaci are reported in scattered cases and details are listed in Table 3. With the development of detection technology, mNGS became a routine examination for etiology. Therefore, more and more C. psittaci pneumonia was diagnosed and treated according to guidelines. Our literature review summarized 19 articles including 69 C. psittaci pneumonia patients, Patients in 11 articles were identified by mNGS, including 9 articles were reported in China. In recent years, the reports of mNGS for C. psittaci pneumonia diagnosis have increased, especially in China. We found that most patients had a history of exposure to avian or poultry. Therefore, epidemiological data combined with mNGS detection is helpful for the early diagnosis of C. psittaci pneumonia. Most patients are treated with doxycycline, moxifloxacin, or their combinations. Three patients used ECOM support and they are all improved. Among these 69 patients in our literature review, 65 patients of C. psittaci pneumonia improved and four patients died. In the future, further case-control studies with a large sample size are needed to find better diagnostic methods and better anti-infective drugs. ConclusionsThe history of contact with avian or poultry and the typical symptoms (high fever over 38.5 °C, cough, hypodynamia, hypoxemia, and dyspnea) are important for C. psittaci pneumonia diagnosis. Moxifloxacin, doxycycline, or their combinations are effective treatment options for C. psittaci pneumonia. mNGS is a promising rapid diagnosis tool, which may increase the detection rate and shorten the diagnosis time of C. psittaci pneumonia. Further case-control studies are needed to confirm. AbbreviationsC. psittaci, Chlamydia psittaci; PCR, polymerase chain reaction assay; CF, complement fixation; mNGS, Metagenomic next-generation sequencing; PCT, procalcitonin; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; CT, computed tomography; ECOM, Extracorporeal Membrane Oxygenation; LDH, lactate dehydrogenase; DIC, disseminated intravascular coagulation; ARDS, acute respiratory distress syndrome. Data Sharing StatementNot applicable. Ethics Approval and Informed ConsentThe Ethics Committees of the Second Xiangya Hospital of Central South University (LYF-2020021) approved this study. Informed consents were obtained from patients and guardians. AcknowledgmentsWe thank the patients enrolled in our study. Author ContributionsAll authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work. All authors have read and approved the manuscript. FundingNo funding or sponsorship was received for this study or publication of this article. DisclosureThe authors report no conflicts of interest in this work. References1. Balsamo G, Maxted AM, Midla JW, et al. Compendium of measures to control chlamydia psittaci infection among humans (Psittacosis) and Pet Birds (Avian Chlamydiosis), 2017. J Avian Med Surg. 2017;31(3):262–282. doi:10.1647/217-265 2. 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