Severe Acute Respiratory Syndrome

Abstract The immune-inflammatory response during the acute phase of COVID-19, as assessed using peak body temperature (PBT) and peripheral oxygen saturation (SpO2), predicts the severity of chronic fatigue, depression and anxiety symptoms 3–4 months later. The present study was performed to examine the effects of SpO2 and PBT during acute infection on immune, oxidative and nitrosative stress (IO&NS) pathways and neuropsychiatric symptoms of Long COVID. This study assayed SpO2 and PBT during acute COVID-19, and C-reactive protein (CRP), malondialdehyde (MDA), protein carbonyls (PCs), myeloperoxidase (MPO), nitric oxide (NO), zinc, and glutathione peroxidase (Gpx) in 120 Long COVID individuals and 36 controls. Cluster analysis showed that 31.7% of the Long COVID patients had severe abnormalities in SpO2, body temperature, increased oxidative toxicity (OSTOX) and lowered antioxidant defenses (ANTIOX), and increased total Hamilton Depression (HAMD) and Anxiety (HAMA) and Fibromylag...

Share on Pinterest A recent study used computational methods to identify novel compounds that activate receptors involved in pain modulation without sedation. Peter Dazeley/Getty Images Due to the risk of addiction associated with the prolonged use of prescription opioids, there is an urgent need for non-opioid alternatives for the treatment of chronic pain. Drugs such as dexmedetomidine that bind to the norepinephrine alpha-2a (α 2a ) adrenergic receptor are effective analgesics, but their sedative effects limit their widespread use. A recent study used computational methods to identify novel compounds that could activate α 2a -adrenergic receptors to relieve pain in mouse models without causing sedation. Further research is needed to assess the side effects of these drugs and optimize the compounds for therapeutic use. Research on non-habit-forming alternatives to opioids for pain relief is ongoing. In a recent study, researchers used computational methods to identify novel compounds...

Lactose intolerance is a condition that occurs when the body cannot digest lactose. In some people, this condition may cause constipation, among other symptoms. Constipation is a condition in which bowel movements are infrequent or hard to pass. It can also be a symptom of other medical conditions, including lactose intolerance. Lactose is a sugar in milk and dairy products that the lactase enzyme breaks down. Lactose intolerance is a digestive disorder that affects about 68% of the world's population. It is due to a shortage of lactase, which is responsible for breaking down the sugar in milk. Lactase breaks down lactose into glucose and galactose, which the cells in the small intestine then absorb. A person with this condition cannot digest milk and other dairy products because their gut lacks this enzyme. This article will explore whether lactose intolerance can cause constipation, lactose intolerance symptoms, how to manage and treat lactose intolerance, other causes of consti...

More than 100 volunteers came together at St. Paul's Hospital on Saturday morning, kicking off the construction of the iconic Lights of Hope fundraising display. The grand holiday display will take around six weeks to construct, with the unveiling of 250 twinkling stars set for Nov. 17. The goal is to raise $3.6 million, which will go towards critical equipment, life-saving research and community programs in the Providence Health Care region. Read more: Runners in Kelowna raise funds for retired military and police dogs The Lights of Hope campaign provides an opportunity for donors to support healthcare needs which helps to provide life-saving equipment and patient comforts. "We know health care is on its back foot and this is the opportunity for the community to come together and help at the darkest moments of the year," said Cecilia Tupper, with St. Pauls Foundation. According to the foundation, The Lights of Hope campa...

Keratitis is a pathological condition involving inflammation of the cornea. It can be an infectious or non-infectious disease. The causative organisms of keratitis are categorized as bacteria, viruses, fungi, or parasites. The viruses responsible for causing keratitis are herpes simplex virus (HSV), varicella-zoster virus, and adenoviruses. The clinical features of this infection may range from pain and redness of the eye to scarring of the cornea or blindness. We present the case of a 71-year-old elderly female patient suffering from viral (HSV) keratitis. She was referred to the department of ophthalmology with complaints of diminution of vision and watering in the right eye associated with pain and redness for one month, which was progressive and gradual in onset. On local examination, the surface of the cornea was irregular in the right eye, with the presence of old keratitis precipitates. Viral infection is the second leading cause of keratitis and is very common in the western ...

Blueberry muffin rashes on babies involve blue, purple, red, or gray spots that are widespread on the body, face, and extremities. The term often links to congenital rubella, but blueberry muffin rashes may have other causes . Let's take a look at what a blueberry rash on a baby might look like, what might cause it, when to contact the doctor for a diagnosis, and how doctors can treat these rashes. Doctors first used the term "blueberry muffin rash" in the 1960s during an epidemic of rubella among newborns. Doctors noticed that babies with rubella developed rashes that resembled blueberry muffins. Although these types of rashes are rare in newborns , it's possible that a pregnant person with rubella can pass this infection along to their baby. Babies who get rubella while in the womb may experience a combination of symptoms after birth, including a blueberry muffin type of rash. A baby getting rubella while in the womb is a common cause of blueberry muffin rash. But...