“Study hints that supplements may reduce COVID-19 risk in females - Medical News Today” plus 1 more

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Study hints that supplements may reduce COVID-19 risk in females - Medical News Today Posted: 10 Dec 2020 12:00 AM PST The research found small but significant decreases in the risk of SARS-CoV-2 infection among females — but not males — who took multivitamins, vitamin D, omega-3 fatty acids, or probiotics. Researchers at King's College London, in the United Kingdom, analyzed data from 1.4 million users of the COVID Symptom Study app in the U.K., the United States, and Sweden. The participants answered questions about their regular use of dietary supplements. The app users also reported results from COVID-19 tests and whether they had experienced symptoms of the illness. "Our research is an observational study and not a clinical trial, so we can't make strong recommendations based on the data we have," cautions senior researcher Dr. Cristina Menni, of the School of Life Course Sciences, at King's. Stay informed with live updates on the current COVID-19 outbreak and visit our coronavirus hub for more advice on prevention and treatment. "Until we have further evidence about the role of supplements from randomized controlled trials, we recommend following the [National Health Service] guidelines on vitamin usage as part of a healthy, balanced diet," she adds. The study, which has not yet been peer-reviewed, has been uploaded to the preprint server MedRxiv. The researchers were surprised to find that only females appeared to benefit from taking the four supplements in question. They cite, however, several studies that have found that females have more robust immune systems, which may mean that their immune defenses get more of a boost from supplements. Alternately, females may be more likely to wear masks or wash their hands than males, which could increase the apparent protective effects of taking supplements. "These are interesting results, but due to the way the study has been conducted, these data absolutely cannot tell us that taking such supplements 'protects' against infection [resulting in] COVID-19," says Naveed Sattar, a professor of metabolic medicine at the University of Glasgow, in the U.K., who was not involved in the research. "It may be that by being more health-conscious, some women are less likely to become infected, so that it's the behaviors that explain these results, not the supplements," he hypothesizes. Seif Shaheen, a professor of respiratory epidemiology at Queen Mary University of London, adds that the researchers had not accounted for factors such as income and educational attainment in their analysis. "A major concern is that these findings may be confounded by socioeconomic status, given that individuals of higher status are more likely to take supplements and are also less likely to become infected with SARS-CoV-2," he cautions. Out of 327,720 users of the app in the U.K. who had each had a polymerase chain reaction or serology test for SARS-CoV-2, 175,652 reported having used supplements regularly since the beginning of the pandemic. The study sample was predominantly female, at 66.8%. In total, 10,508, or 6.0%, of the supplement users had tested positive for the novel coronavirus, while 13,013, or 6.6%, of the nonusers had received positive results. After the researchers had adjusted for other factors that could contribute to COVID-19 risk, they found that four supplements were associated with reduced risk. Taking probiotics, multivitamins, omega-3 fatty acids, or vitamin D was associated with a 14%, 13%, 12%, and 9% lower risk of COVID-19. Taking vitamin C, zinc, or garlic supplements was not associated with any reduced risk. When the researchers broke down the numbers by sex, they found reduced risk associated with probiotics, multivitamins, omega-3 fatty acids, and vitamin D in females only. After analyzing data from app users in the U.S. and Sweden, the researchers found similar associations between supplement use and confirmed SARS-CoV-2 infections. Among the 993,365 regular users of the app worldwide who had not undergone testing, 126,556 had reported a loss of smell or taste. This suggests that they likely had COVID-19. When the researchers analyzed data from these individuals, they found a small but significant reduction in risk among both males and females who regularly took omega-3 fatty acids, multivitamins, vitamin D, or probiotics. During the ongoing pandemic, vitamin D has attracted a lot of media attention following the publication of studies suggesting that it may have a protective effect. The evidence to date has been mixed and inconclusive, however. Two clinical trials underway may provide more clarity — one run by the Queen Mary University of London and the other by the Angers University Hospital, in France. Meanwhile, the researchers behind the present study acknowledge several limitations. For example, all the participants were "self-selected." They chose to download and use the app and so may not be representative of the general population. In addition, the information that they provided may be inaccurate. For example, they may have started taking supplements after developing symptoms. The authors emphasize that, as an observational study, their research cannot provide definitive proof that taking any supplement reduces the risk of COVID-19. They conclude: "Large randomized controlled trials of selected supplements testing their protective effects and also possible adverse effects on disease severity are required before any evidence-based recommendations can be made. We eagerly await the result of ongoing trials, including [those investigating] vitamin D and COVID risk." For live updates on the latest developments regarding the novel coronavirus and COVID-19, click here.

1 In 10 People Experience Long Covid For 3 Months Or More - IFLScience Posted: 18 Dec 2020 05:48 AM PST Around one in five people have lingering side-effects of Covid-19 up to five weeks after initially falling sick, according to a big new analysis in the UK. Furthermore, around one in 10 people with Covid-19 appear to experience nagging symptoms for 12 weeks or longer.  The UK Office for National Statistics (ONS) has released preliminary information from its report on the prevalence of "long Covid," the lingering impact of the coronavirus infection that can sometimes last for months. A number of other studies across the world have attempted to tackle this question before, but this new work is one of the biggest and most extensive investigations yet. The ONS says the report is "very much a work in progress" and still in its infancy, but it's revealed some important insights into the mysterious phenomenon of long Covid.  Using data from the ONS Infection Survey on hundreds of thousands of people in the UK, the report found that during the last week of November 2020 around 186,000 people in England were living with long Covid symptoms that had persisted for between five and 12 weeks.  The most commonly reported symptom was fatigue, followed by a cough, headache, loss of taste, loss of smell, sore throat, fever, shortness of breath, nausea, diarrhea, and abdominal pain. "These preliminary data are very concerning," commented Dr David Strain, a senior clinical lecturer at the University of Exeter Medical School, who was not directly involved in the survey.  "These data also give an insight into the range of complications occurring, for example, the risk of a heart attack, stroke or heart failure being nearly 12 times higher in Covid patients than in comparable patients hospitalized with other infections, and the rates of developing diabetes or kidney failure being ~9 and ~10 times higher respectively," he added.  "These confirm what we have seen working on the Covid wards, that this virus is more than a simple respiratory infection, but is a multi-system disease." Many other reports have shown Covid-19 infections can also spark psychiatric disorders, such as anxiety or depression, within three months of falling sick, although this was not detailed in the new ONS survey. One widely reported symptom is a lingering feeling of "brain fog," where people struggle to concentrate and experience memory loss. Researchers are still grappling to understand long Covid. While persisting symptoms can be seen with other viral infections, most often post-viral fatigue or a post-viral cough, lingering side-effects appear to be a hallmark of Covid-19. There are lots of ideas about why SARS-Cov-2 causes these long term complications, but no definitive answers. A report by the British National Institute for Health Research (NIHR) in October proposed the idea that long Covid may not be one syndrome but possibly up to four different syndromes: permanent organ damage, post-intensive-care syndrome, post-viral fatigue syndrome, and continuing Covid-19 symptoms. Whatever the cause, long Covid is a problem that could cause misery for millions of people worldwide. Worryingly, it also opens up the very real possibility of Covid-19 causing further health concerns in the years and decades to come, which could a huge strain on healthcare systems across the world.  "Although post-viral symptoms are common, whether after flu or other coronaviruses, the scale of this pandemic and the potential number of infected people with long Covid is unprecedented, and poses yet another Covid-19-related public health challenge," explained Dr Amitava Banerjee, Associate Professor in Clinical Data Science and Honorary Consultant Cardiologist at University College London.

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