Flaxseed supplementation could benefit PCOS sufferers and older ... - NutraIngredients-Asia
The synthesis and metabolism of sex hormones are influenced by various factors including genetics, dietary intake, physical activity, and environment. While some studies have suggested that the consumption of flaxseed may regulate sex hormone levels due to its phytoestrogen content such as lignans, existing data is limited and inconsistent. To examine the effect of flaxseed intake on sex hormone profile, researchers in Iran carried out a systematic review and meta-analysis of 10 randomised clinical trials (RCTs) that were searched up to March 2023. Specifically, the sex hormones included in this meta-analysis are follicle-stimulating hormone (FSH), sex hormone-binding globulin (SHBG), free androgen index (FAI), total testosterone (TT), and dehydroepiandrosterone sulphate (DHEAS). Results showed that flaxseed supplementation did not significantly decrease FSH, although studies with an intervention duration of 12 or more weeks reflected a more significant reduction in FSH levels. In addi...