Severe Acute Respiratory Syndrome

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The urinary antiseptic methenamine hippurate (Hiprex) was non-inferior to antibiotic prophylaxis in women with a history of recurrent urinary tract infections (UTI), according to results from the ALTAR trial. Over the course of 12 months, the incidence of antibiotic-treated UTI was 0.89 and 1.38 episodes per year in patients treated with prophylactic antibiotics or methenamine hippurate, respectively (absolute difference 0.49 episodes, 90% CI 0.15-0.84), reported Christopher Harding, MD, of Freeman Hospital in Newcastle upon Tyne, England. The agent met the study's non-inferiority margin that was defined as a difference of one UTI episode per year, Harding said in a presentation at the European Association of Urology (EAU) annual congress. Results were previously reported in The BMJ . "Let's remember that daily antibiotics are the current guideline-recommended standard," he noted. "I think that this trial provides good evidence that methenamine hippurate co...

The U.S. Department of Health and Human Services (HHS), in collaboration with the U.S. Department of Defense (DOD), today announced an agreement to purchase 66 million   doses of Moderna's bivalent COVID-19 vaccine booster candidate for potential use in the fall and winter. This contract announcement follows a recommendation by the FDA last month that vaccine manufacturers update their existing COVID-19 vaccines to create a bivalent booster that can target BA.4 and BA.5 Omicron subvariants. Today's purchase is in addition to the 105 million bivalent COVID-19 vaccine booster doses the U.S. government purchased recently from Pfizer for potential use later this year, pending FDA authorization and a recommendation by CDC. Pending those FDA and CDC actions, HHS would receive the first deliveries of the Moderna and Pfizer vaccine booster doses in early fall. "We must stay vigilant in our fight against COVID-19 and continue to expand Americans' access to the best...

Share on Pinterest A new study has identified changes in brain microstructures in women who experience racism. Image credit: mikroman6/Getty Images. A new study looks at the brains of Black women who reported having experiences with racial discrimination. The goal of the study was to determine whether racial discrimination could affect the brain. After doing MRI scans on the women's brains, the researchers found changes in their white matter. The researchers believe that these changes can contribute to adverse health outcomes. Experiencing racism can impact both physical and mental health, and with this in mind, researchers from Emory University in Atlanta wanted to find out how this form of discrimination impacts the brain's microstructures. The research team utilized MRI scans to assess the brains of Black women who had experienced racism. According to the researchers, this is the first report of associations between this form of discrimination, white matter integrity, and in...

Abstract Bone and joint infections (BJI) are one of the most difficult-to-treat bacterial infection, especially in the era of antimicrobial resistance. Lytic bacteriophages (phages for short) are natural viruses that can selectively target and kill bacteria. They are considered to have a high therapeutic potential for the treatment of severe bacterial infections and especially BJI, as they also target biofilms. Here we report on the management of a patient with a pandrug-resistant Pseudomonas aeruginosa spinal abscess who was treated with surgery and a personalized combination of phage therapy that was added to antibiotics. As the infecting P. aeruginosa strain was resistant to the phages developed by private companies that were contacted, we set up a unique European academic collaboration to find, produce and administer a personalized phage cocktail to the patient in due time. After two surgeries, despite bacterial persistence with expression of small colony variants, the patient he...

Schizophrenia is a mental health disorder that disturbs your thinking and perception. This affects your interactions with the world. Advertising Policy Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy Schizophrenia not only refers to a single condition, but also a spectrum of conditions that involve psychotic symptoms like: Hearing voices or noises. Becoming very paranoid. Believing you have unusual powers. Thinking others control your thoughts, or vice-versa. Believing world events are connected to you. It can be a long road to diagnosis, however. People — and families — are often in denial. After all, it's a tough diagnosis to accept. Psychiatrists may not see all of the symptoms of a person's schizophrenia right away. And substance use may further cloud the diagnostic p...

You do not have to stop working to receive Social Security benefits, but it may affect what you collect. Benefits are available to access at 62 years of age, and many seniors continue to work after opting to start their benefit payments. However, the amount you earn could potentially cause some or all of your Social Security benefits to be withheld, depending on your age and your income. Using a 2019 example from The Motley Fool, if you are due to receive $16,800 in Social Security income, and you earn $60,000 per year, you will have earned $42,360 above the $17,640 allowable earnings threshold ($60,000 minus $17,640). Because benefits are reduced $1 for every $2 earned, so you can divide the excess earnings of $42,360 by 2 and see that $21,180 in benefits would be withheld. In this scenario, your entire Social Security benefit for that year would be withheld because it is more than the benefits you received. The Social Security Administration website has ple...

While bats are found in abundance in most parts of the world, particularly in tropical and temperate climates, they rarely cause problems to human beings. However, over the past several years, bats have emerged as potential vectors of several viruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused the ongoing coronavirus disease 2019 (COVID-19) pandemic. A new iScience  journal tudy examines the role of bats as reservoirs of several viruses and the factors that contribute to the emergence of these viruses. Study:  Molecular, Ecological, And Behavioural Drivers of The Bat-Virus Relationship. Image Credit: Bernd Wolter / Shutterstock.com Introduction Of the over 1,400 bat species of the order Chiroptera, all belong to one of two suborders, including Yinpterochiroptera and Yangochiroptera. Bats are considered keystone species, as they control the infestation of nocturnal insects and pests, thus benefiting agr...

LITTLE ROCK, AR. (April 21, 2022) – Arkansas Children's Research Institute (ACRI) is awarding two early-career investigators up to $75,000 each to fund their work as the 2022 Marion B. Lyon Revocable Trust New Scientist Development recipients. The annual award supports highly promising beginning researchers in their efforts to become independent investigators and fosters an environment where young scientists can flourish. The 2022 honorees are:   Akilah A. Jefferson, MD, MSc, an assistant professor of Allergy and Immunology in the University of Arkansas for Medical Sciences (UAMS) College of Medicine who also sees patients at Arkansas Children's Hospital (ACH). With research focused on asthma and health disparities, Dr. Jefferson has a special interest in population health, health policy and social determinants affecting asthma outcomes. Asthma is the most common chronic condition among children in the United States, affecting more than 5.5 milli...